六神丸组方配伍对雄黄肾脏毒性的影响文献综述

六神丸组方配伍对雄黄肾脏毒性的影响摘要：雄黄是经典中成药的常见组成药物，因含有硫化砷类成分，其安全性备受关注。

本文通过大鼠体内炎症磷脂介质水平的改变，着重分析了雄黄在实验动物慢性暴露的安全性研究数据。

特别是在经典名方六神丸组方配伍中，发现对雄黄的减毒效应。

提示雄黄制剂在临床合理剂量和用药时间下，存在一定安全性的可能。

关键词：雄黄六神丸砷配伍减毒Effect of Liushen Pill prescription on kidney toxicity of RealgarAbstract：Realgar is a common component of classical Chinese medicine preparation, which has attracted much attention due to high content of arsenic sulfide. In this paper, by changing the level of phospholipid medium in rats, the safety data on the chronic exposure of Realgar in experimental animals were analyzed.In particular, the classic Chinese medicine Liu-shen-wan compatibility reduced realgar -induced toxicity. That illustrated that the Chinese medicine preparations containing realgar clinically used at low dose and reasonable medication time, have certain drug safety. Keywords:realgar, Liushen Wan, realgar, compatibility attenuated雄黄又名黄金石、天阳石、石黄、鸡冠石,为硫化物类雄黄族雄黄(Realgar),具有解毒杀虫,燥湿巧疲,截拒的功效。

雄黄在临床上的应用非常广泛,现有的很多成方制剂都含有雄黄,其中不乏六神丸、牛黄解毒丸、安宫牛黄丸等名方。

纵观历代方剂和中成药,雄黄作为常用矿物药,其用药频次较离。

同时,随着中医药行业的不断发展,兼具疗效和毒性于一身的雄黄越来越为相关部口所重视。

雄黄毒性源于其中含有的砷。